IM Doc pt 37
May. 31st, 2022 02:35 pmSince Covid is winding down as a theme there, I'll be selecting IM Doc's comments for those that relate to medical issues. The first one, though, is quasi-medical but just too good to pass up:
IM Doc
One thing is for sure. I would be very very careful about medical evaluations done over TV or magazines. There is nothing like seeing and feeling the patient’s body and organs in your own hands and eyes. There are exceptions to this. Diagnosis of dementia and other neuro problems is often patently obvious just by watching behavior on TV. For example, Joe Biden – his neurologic issues are apparent for any trained eye to see – the marked change from baseline, the irrational bursts of anger, the gradually worsening and severe gait disturbance ( that particular type is very associated with dementia), the slouch when he walks, the way he holds his face/eyes, the confusion, getting lost in speech, having his family or handlers constantly cover for him, etc . A bunch of disparate symptoms that are behavioral and obvious are apparent. If this type of patient showed up in my office, after a few minutes of observation, I would order a neuro-cognitive evaluation instantly.
IM Doc has an entire large-ish very vaxxed family (3-4 shots each) that went to the Star Trek convention and all now have Covid. He adds that George Takei had been putting up hateful tweets about the unvaxed and he was at this convention:
Here's Yves, being dense ("They're not wearing masks!") rather than astute ("They're vaccinated!) - but anyway...Various Covid Updates
While the lack of any big Covid news absent the Administration’s foot shuffling when its mask mandate was shot down, that does not mean Covid should be ignored. Our Covid brain trust and readers have been sending news.
Fresh from IM Doc:
62 patients who are COVID positive – either ill themselves or found during testing or primary contacts. Again, zero unvaccinated. Of the 62 -35 were primary vaccinations, an additional 11 are with one booster – and the other 16 were 2 boostered. I had no partial VAX or J&J this week.
ZERO unvaccinated. That makes 7 weeks of not seeing a single unvaxxed patient. Colleagues all over America are reporting similar issues – usually less than 5% unvaxxed are being reported.
Something is going on. I do not believe for a minute it is because the unvaxxed have decided not to seek care. Nor is it young and healthy excuse – many of the positive vaxxed patients are young and healthy.
I am becoming increasingly concerned that this may go pear-shaped if/when a more noxious variant emerges.
And another alarming issue is rearing its ugly head again. THIS TIME MUCH EARLIER. This did not start last year until the mid to late summer. I have had to admit 3 patients this week – all adults – all 3 with RSV pneumonia. All 3 fully vaxxed and double boosted for COVID. One of these was a little old lady with DM – the other 2 were young men, healthy and robust. All had severe pneumonia. I have never admitted an adult with RSV until the COVID vaccines. Not once in 30 years. Here we go again.
Thankfully, so far, the COVID has been pretty mild. None required admission this week. However, I am certain that at most 5-10 were reported to the health officials. Severe under-reporting is going on. THERE IS A REASON THE CDC and BIDEN PROVIDED AMERICA WITH THE FREE TESTS – AND IT HAS NOTHING TO DO WITH PATIENT CARE.
Needless to say, it’s not encouraging to see the vaccinated feeling sick enough that they need to see doctors. Regarding the apparent underrepresentation of the unvaccinated, it may be that they are on average more cautious than the vaccinated, who were sold repeatedly on the idea that being vaccinated protected them from getting Covid, or at least from getting all that sick. While the plural of anecdote is not date, the two unvaccinated people I know are insanely careful, hardly seeing anyone and well masked when they do.
Lambert’s Covid data wraps have shown the MA wastewater count rising to a level that was at the high end for all waves before Omicron. It had fallen off this week, but that may be an artifact of Easter/spring vacation holidays.
Additional cheery news:
There is a theoretical risk that serial covid infections could predispose to a future more severe reinfection
It's very simple, no need to go wild
The recent VA paper lends this theory of decompensation credibility
— Anthony J Leonardi, PhD, MS (@fitterhappierAJ) April 18, 2022
It's a complex multivariable system. Let's see if infections progressively get milder. I think not. https://t.co/PnF6hIPtPV
— Anthony J Leonardi, PhD, MS (@fitterhappierAJ) April 18, 2022
Note this hypothesis could also help explain what IM Doc is seeing: individuals who got asymptomatic cases (as in they may not have realized they contracted Covid) before now getting symptomatic ones.
More variants and more waves:
If COVID rising again in Gauteng, South Africa; it’s likely driven in part by emergence of B4, B5 omicron variants
Experimental evidence indicates vaccine induced antibodies don’t neutralize B4, B5 as well as B1, B2 and immunity from prior B1 infection may not be as protective https://t.co/vbDYYSD1Ve
— Scott Gottlieb, MD (@ScottGottliebMD) April 22, 2022
And it’s growing!
R is above 1 in all provinces other than Limpopo. So cases are rising rapidly in most provinces. pic.twitter.com/wA3A0cWZFA
— Louis Rossouw (@lrossouw) April 21, 2022
Scientist GM points out this wave is a month ahead of schedule. He also points out the inconsistency in Gottlieb’s carrying water for the Administration:
In the meantime, in the US, we have some not nice subvariants to watch (hat tip guurst):
Signs of the 6th wave of the #SARSCoV2 pandemic are multiplying.
In the near future, we seem to be saying '#BA2, #BA4, #BA5 waves are now in the US'. https://t.co/YnO0b9kXIs
— Abdulkadir YILMAZ (@a__virologist) April 22, 2022
The #BA2 and BA.2 subvariants rates has increased enough to cause a wave.
In addition, #BA4 cases are seen in some regions.
We know that BA.4 is much more contagious than BA.2. pic.twitter.com/HgELdca8oS
— Abdulkadir YILMAZ (@a__virologist) April 22, 2022
In particular, the #BA2 subvariant BA.2.12.1 needs to be followed carefully.
BA.2.12.1 seems to have a 68% growth advantage over BA.2.https://t.co/KkHfLTrMQ0
— Abdulkadir YILMAZ (@a__virologist) April 22, 2022
So it’s too early to even try to call trajectories, but these emerging variants have the potential to cause yet more trouble, particularly in the US, where we are again throwing caution to the wind.
____
There's plenty to chew on in the following post (more than just IM Doc's comment, which'll put you off pharmaceuticals if you aren't already, that follows):
Will Pfizer’s Paxlovid Be the Game-Changer that Saves Biden’s “Test to Treat” Program?
Not medical-related, but still entertaining:
UK monkeypox alert as health chiefs detect another FOUR cases of killer virus with NO links to Africa — as gay and bisexual men are urged to look out for ‘unusual rash’ Daily Mail. IM Doc:
There is apparently no clue the transmission line in the UK. This virus has a fatality rate of 10%. Only supposed to be mildly to moderately contagious.
Scientist GM’s reply:
While it's possible IM Doc might come and post in the last hours of 5/31, I'm making a gamble that he won't, so we're all caught up for now!Yeah, that means community spread. Not good, but then there haven’t been rampant out of control epidemics of it in Africa, so probably won’t cause the apocalypse it would have if it was a bit more contagious.
Although there is a wrinkle here, which is that smallpox vaccination works against this too, and over time smallpox immunity has been diluting more and more as vaccination against it stopped in the 1970s. So we might end up with the monkeypox adapting better to H2H spread, the boomer generation dying out, and then we’ll have a big problem
Has this been posted? If so, I missed it and I’m sorry.
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac109/6561438
The Concept of Classical Herd Immunity May Not Apply to COVID-19
David M Morens, Gregory K Folkers, Anthony S Fauci
The Journal of Infectious Diseases, jiac109, https://doi.org/10.1093/infdis/jiac109
Published:
31 March 2022